Dr Gan, Samuel Ken En - Profile

UserID: 8099
Email: samuelg@bii.a-star.edu.sg
Organization: Bioinformatics Institute (BII), A*STAR
Affiliated Organizations : p53 Laboratory (p53Lab), A*STAR
James Cook University, Singapore
Editor in Chief, SPAMD, Springer
URL : http://www.bii.a-star.edu.sg/research/trd/apd.php
My Page
Keywords :
Bioinformatics apps
drug design
viral mutations
Antibody engineering

Last Login Date : 24/02/2018 17:15:08
Last Updated Date : 24/02/2018 17:44:18

Summary :
Research Area : Allergy
Bioinformatics / Medical Informatics
Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Biotechnology: Others
Cellular Immunology
Genetic Engineering and Enzyme Technology
Genetic Technologies: Transformation, Site-directed Mutagenesis, etc
Infectious Diseases
Learning, Memory, Cognition and Language
Microbiology: Others
Psychological Methodology, Design and Analysis
Virology
Other: scientific phone apps
Education :
Others 2014 Stanford University United States
Others 2013 Santa Fe Institute United States
Others 2013 Santa Fe Institute United States
Others 2013 Temasek Polytechnic Singapore
Others 2010 Open University United Kingdom
Bachelor 2009 Open University, UK United Kingdom
Master 2009 Birkbeck College United Kingdom
Others 2009 King's College London United Kingdom
PhD 2009 King's College London United Kingdom
Others 2008 KILT, King's College London United Kingdom
Bachelor 2005 University College London United Kingdom
Others 2002 Temasek Polytechnic Singapore
Others 2001 Temasek Polytechnic Singapore
Singapore Based Committee:
Volunteer Committee 2015-Current A*STAR CSR Singapore

Employment History

Designation Duration Organization Country
Founding Editor-in-Chief 2015-Current Scientific Phone Apps and Mobile Devices Journal Singapore
Assistant PI 2015-Current Bioinformatics Institute Singapore
Team Leader 2013-2015 Bioinformatics Institute Singapore
Product Development Scientist 2013-2014 Quintech LifeSciences (50% seconded by A*STAR) Singapore
Assistant Head 2010-2011 A*STAR HQ Singapore

Publications

Author Title Journal Year Vol: Page
Ling WL, Lua WH, Poh JJ, Yeo JY, Lane DP, Gan SKE Effect of VH-VL families in Pertuzumab and Trastuzumab recombinant production, Her2 and FcgIIA-binding. Frontiers in Immunology 2018  
Phua SX, Lua WH, Gan SKE Role of FcaR EC2 region in extracellular membrane localization Cell Cycle 2018  
Lua WH, Ling WL, Yeo JY, Poh JJ, Lane DP, Gan SKE The effects of Antibody Engineering CH and CL in Trastuzumab and Pertuzumab recombinant models: Impact on antibody production and antigen-binding Scientific Reports 2018  
Chiang RZH, Gan SKE, Su CTT. A computational study for rational HIV-1 non-nucleoside Reverse Transcriptase inhibitor selection and the discovery of novel allosteric pockets for inhibitor design Bioscience Reports 2018  
Su CTTC, Kwoh CK, Verma CS, Gan SKE. Modeling the full length HIV-1 Gag polyprotein reveals the role of its p6 subunit in viral maturation and the effect of non-cleavage site mutations in protease drug resistance. Journal of Biomolecular Structure & Dynamics. Journal of Biomolecular Structure & Dynamics 2017 1-12
Su CTTC*, Ling WL*, Lua WH, Poh JJ, Gan SKE The role of Antibody V? Framework 3 region towards Antigen binding: serendipitous effects on recombinant production and Protein L binding Scientific Reports 2017 7: 3766
Sim JZ, Nguyen PV, Zang Y, Leow MKS. Gan SKE. Thyroid-SPOT: Thyroid treatment management app. Scientific Phone Apps and Mobile Devices 2017 3: 4
Budiano IH, Gan SKE. APD Volumetric App: Android App for the quantification of reagents. Scientific Phone apps and Mobile Devices 2017 3:7
Wong CF, Yeo JY, Gan SKE APD Colony Counter App: Using Watershed Algorithm for improved colony counting Nature Methods Application Notes 2017 doi:10.1038/ an9774
Ng KM, Wong CF, Liang AX, Liew YH, Yeo JY, Lua WH, Qian XJ, Gan SKE APD SpectBT: Arduino-based mobile vis-Spectrophotometer. Nature Methods Application Notes 2017 doi: 10.1038/an9827
Lua WH, Ling WL, Su CTT, Yeo JY, Verma CS, Eisenhaber B, Eisenhaber F, Gan SKE. Discovery of a novel splice variant of Fcar (CD89) unravels sequence segments necessary for efficient secretion: a story of bad signal peptides and good ones that nevertheless do not make it. Cell Cycle 2017 doi: 10.1080/1538410
Su CTT, Ling WL, Lua WH, Haw YX, Gan SKE Structural analyses of 2015-updated drug-resistant mutations in HIV-1 Protease: An implication of Protease Inhibitor cross-resistance. BMC Bioinformatics 2016 Vol 17, Suppl X, S12
Wong CF, Yeo JY, Gan SKE APD Colony Counter App: Using Watershed Algorithm for improved colony counting. Nature Methods Application Notes 2016 doi:10.1038/ an9774
Gan SKE, Koshy C, Nguyen PV, Haw YX An Overview of clinically and healthcare related apps in Google and Apple app stores: connecting patients, drugs, and clinicians. Scientific Phone Apps and Mobile Devices 2016 Vol 2:8. doi: 10.118
Nguyen PV, Ghezal A, Hsueh YC, Boudier T, Gan SKE, Lee HK Optimal processing for gel electrophoresis images: Applying Monte Carlo Tree Search in GelApp. Electrophoresis 2016 doi: 1.1002/elps.201
Sim JZ*, Nguyen PV*, Zang Y, Gan SKE. DNA2App: Mobile sequence analyzer. Scientific Phone Apps and Mobile Devices. 2016 Vol 2(2). doi: 10.11
Chew ASQ, Yu YT, Chua SW, Gan SKE. The effects of familiarity and language of background music on working memory and language tasks in Singapore. Psychology of Music 2016 doi: 10.1177/0305735
Gan SKE, Poon JK The World of Biomedical Apps: their uses, limitations, and potential. Scientific Phone Apps and Mobile Devices 2016 Vol 2:6. doi: 10.118
Ng KM*, Nguyen PV*, Sukiman IF, Gan SKE VibraTilt: Accelerometer & Gyroscope measurement app. Scientific Phone Apps and Mobile Devices. 2016 Vol 2(5). doi: 10.11
Gan SKE., Goh BYL. Editorial: A dearth of apps for psychology: the mind, the phone, and the battery. Scientific Phone Apps and Mobile Devices 2016 doi: 10.1186s41070-0
Sim JZ*, Nguyen PV*, Zang Y, Gan SKE. DNA2App: Mobile sequence analyzer. Scientific Phone Apps and Mobile Devices. Scientific Phone Apps and Mobile Devices 2016 Accepted
Gan SKE., Lim MJ Chapter 2: "Awareness of Others "in "First Class Behaviours for a First World Nation" James Cook University SG50 Book. 2015 E-Published 16 Dec 2
Sim JZ, Nguyen PV, Gan SKE, Leow MKS Thyroid-SPOT for Android and iOS. A*STAR Exploit (Invention Disclosure) 2015 SICS/Z/09136
Lua WH*, Gan SKE*,#, Lane DP, Verma CS# A search for synergy in the binding kinetics of Trastuzumab and Pertuzumab whole and F(ab) to Her2 NPJ Breast Cancer 2015 Vol1: Article 15012
Gan SKE With GelApp, Say Goodbye to Band Size Estimations! AES Newsletter. AES Newsletter. 2015 Aug 2015, Vol 20, Is
Gan SKE Editorial: scientific Apps: design, considerations, and functions. Scientific Phone Apps and Mobile Devices 2015 Vol 1(1). doi:10.118
Yew SH, Lim KMJ, Haw YX, Gan SKE. The Interaction between Perceived Stress, Optimisim, Life Satisfaction and Physical Health in the Singaporean Asian Context Asian Journal of Humanities and Social Sciences 2015 Vol 3, Issue 1.
Gan SKE The Use of Smartphone Apps in Biomedical Research BioSpectrum 2015 March Issue
Sim, JZ.*, Nguyen, PV.*, Lee, HK., Gan, SKE. GelApp: Mobile gel electrophoresis analyzer Nature Methods Application Notes 2015 doi:10.1038/an9643
Gan SKE, Lim MJ, Haw YX The Relaxation Effects of Stimulative and Sedative Music on Mathematics Anxiety: A Perception to Physiology Model Psychology of Music. 2015 DOI: 10.1177/0305735
Budianto IH*, Wong CF*, Nguyen PV, Gan SKE StanXY: Standard Curve App for Android. Scientific Phone Apps and Mobile Devices. 2015 Vol 1(2). doi:10.118
Nguyen PV*, Lim JPH*, Budianto IH, Gan SKE PsychVey: Research Survey App. Scientific Phone Apps and Mobile Devices 2015 Vol 1(3), doi:10.118
Poh JJ, Gan SKE. Comparison of Customized Spin-Column and Salt-Precipitation Finger-Prick Blood DNA Extraction. Bioscience Reports 2014 doi:10.1042/BSR20140
Jiang Y,Tan CY,Tan SY, Wong MSF, Chen YF, Zhang L, Yao K, Gan SKE, Verma CS, Tan YJ. SAW Sensor for Influenza A Virus Detection Enabled with Efficient Surface Functionalization. Sensors and Actuators B: Chemical 2014 doi:10.1016/j.snb.20
Nguyen PV, Verma CS, Gan SKE. DNAApp: a mobile application for sequencing data analysis. BIOINFORMATICS 2014 doi: 10.1093/bioinfo
Poh JJ, Gan SKE. The Determination of Factors involved in Column-Based Nucleic Acid Extraction and Purification. Journal of Bioprocessing and Biotechniques 2014 4:157. doi: 10.4172/
Nguyen PV, Gan SKE (Inventors) DNAapp - the first android app for analysis of sequencing files A*STAR Exploit (Invention Disclosure) 2014  
Chan WT, Verma CS, Lane DP and Gan SKE A comparison and optimization of methods and factors affecting the transformation of Escherichia coli Bioscience Reports 2013 33 (6)..doi:10.1042/
Gan SKE (Inventor) Rapid Humanization and Rodentization of Monoclonal Antibodies A*STAR Exploit (Invention Disclosure) 2013 BII/Z/0797
Gan SKE (Inventor) Optimization of nucleic acid extraction kits A*STAR Exploit (Invention Disclosure) 2013 BII/Z/08123
Gan SKE (Inventor) Novel BSL2 platform for RNA-virus drug escape mutation and prediction A*STAR Exploit (Invention Disclosure) 2013 BII/Z/07970
Oh HLJ, Gan SKE, Bertoletti A, Tan YJ Understanding the T cell immune response in SARS coronavirus infection Emerging Microbes and Infections 2012 Sept
Gan SKE Psychoneuroimmunology – Not a mouthful but a hidden and controversial field Open University Psychological Society Publication 2009  
Karagiannis P, Singer J, Hunt J, Gan SKE, Rudman SM, Mechtcheriakova D, Knittelfelder R, Daniels TR, Hobson PS, Beavil AJ, Spicer S, Nestle F, Penichet ML, Gould HJ, Jensen-Jarolim E, Karagiannis SN Characterisation of an engineered trastuzumabIgE antibody and effector cell mechanisms targeting HER2/ neu-positive tumour cells CANCER IMMUNOL IMMUN 2009 Jun;58(6):915-30
Gan SKE Genetic Engineering and Functional Studies of Human IgEs University of London Library, PhD Thesis 2009  
Gan SKE, Hunt J, Marsh PJ, Beavil, AJ, Harries, HE Method (Rapid expression of recombinant Igs) Patent 2008  
Gan SKE Co-Evolutionary Compensatory Mutations in HIV-1 Clade B Gag - Protease University of London Library, BSc (Hons) Thesis 2005  
Gan SKE, Loh CY, Seet HY Hypertension in Young Adults – An Under-Estimated Problem Singapore Medical Journal 2003 44(9):448-52
Tan JE, Wong SC, Gan SKE, Xu S, Lam KP The Adaptor Protein BLNK Is Required for B Cell Antigen Receptor-induced Activation of Nuclear Factor-?ß and Cell Cycle Entry and Survival of B Lymphocytes J BIOL CHEM 2001 276 (23), Issue of J

Prizes/Awards

Description Year Organization/Country
Top 100 World Cross-Domain Innovators, World Class Fusioneer 2017 SP Jain School of Global Management/ Singapore
Marquis Who's Who 2016 Marquis Who's Who/ United States
Judge for National Science Challenge 2015. 2015 A*STAR, Nat Sci Center, Mediacorp/ Singapore
Featured successful alumni of 50 graduates of Singapore Institute of Technical Education and Polytechnics in "Nation of Skilled Talents" SG50 Book. 2015 Singapore/ Singapore
Marquis Who's Who 2015 Marquis Who's Who/ United States
Marquis Who's Who 2014 Marquis Who's Who/ United States
Marquis Who's Who 2013 Marquis Who's Who/ United States
Global Young Scientist Summit 2013 National Research Foundation, PMO/ Singapore
Judge for National Science Challenge Outdoor challenge. 2013 A*STAR, Nat Sci Center, Mediacorp/ Singapore
Marquis Who's Who 2012 Marquis Who's Who/ United States
Marquis Who's Who 2011 Marquis Who's Who/ United States
Marquis Who's Who 2010 Marquis Who's Who/ United States

International Editorship/Advisorship

Description From Year To Year Organisation/Country
Chief Editor of "Scientific Phone Apps and Mobile Devices" journal 2015 2018 Springer/ Singapore
Technical Consultant 2009 2011 Realgene Shanghai Biotech/ China
Chief Editor of "Scientific Phone Apps and Mobile Devices" journal 2018 Current APD SKEG Pte Ltd/ Singapore
Chief Editor of "APD Trove" Student journal 2018 Current APD SKEG Pte Ltd/ Singapore

Collaborations

Collapse Company
Project Institution/Organization Name Description From Year To Year
Biomedical Sciences courses Singapore University for Social Sciences Development of 2 modules for SUSS Biomedical Engineering students in Biomedical Sciences 2018 Current
MSc Laboratory courses Dimensions International College, Cardiff Metropol Laboratory courses for MSc Biomedical Sciences Students 2017 Current
Skillsfuture Bioinformatics Workshop Temasek Polytechnic Development of a Bioinformatics Workshop 2017 2018
Optimization of nucleic acid extraction kits Quintech LifeSciences Pte Ltd Optimization and manufacturing of local nucleic acid extraction kits. 2012 2017
DNA Sequencing Axil Scientific 2014 2016
Collapse Hospital
Project Institution/Organization Name Description From Year To Year
Autoantibodiers in SLE NUHS 2015 Current
Detection of V genes Changi General Hospital 2014 Current
Analysis of drug resistant mutations Tan Tock Seng Hospital 2013 2014
Collapse University
Project Institution/Organization Name Description From Year To Year
Biomodeling of viral proteins NTU CE 2010 Current
Collapse RI
Project Institution/Organization Name Description From Year To Year
Optimization of Therapeutic Antibodies p53 Lab 2012 Current
Bioinspired algorithm for operations research SIMTech 2011 Current
ThyroidSPOT SICS 2015 2015

Grant

Project Title
Wound Care Innovation for the Tropics
Predicting potential drug-resistance mutations of HIV-1 viral proteins
The use of TisXell for immune protein production.
Antibody engineering of therapeutic antibodies
Technology-UP
Piezoelectric surface acoustic wave (SAW) sensors for influenza diagnosis
An investigation into modelling and understanding manufacturing production system and HIV viral reproduction system as a complex system