Assoc/Prof LIM, Kah-Leong - Profile

UserID: 7692
Email: kahleong.lim@duke-nus.edu.sg
Organization: National Neuroscience Institute (NNI)
Department : Research
Affiliated Organizations : National University of Singapore (NUS)
Duke-NUS Graduate Medical School (GMS)

URL : http://www.nni.com.sg/research/nni-laboratories/neurodegeneration/Pages/Home.aspx
My Page
Keywords :
autophagy
mitochondria
neurodegeneration
parkin
proteasome
ubiquitin
Parkinson

Last Login Date : 13/06/2014 23:27:02
Last Updated Date : 13/06/2014 23:48:08

Summary :
Research Area : Neuroscience, Neurobiology & Neurology
Neuroscience, Neurobiology & Neurology: Others
Education :
Others 2001 Johns Hopkins Medicine United States
Others 2000 Harvard Medical School United States
PhD 1999 National University of Singapore Singapore
Scientific Appointment :
Associate Professor (Joint) 2012-Current NUS Physiology Singapore
Principal Research Scientist 2012-Current National Neuroscience Institute Singapore
Associate Professor (Joint) 2009-Current Duke-NUS Graduate Medical School Singapore
Singapore Based Committee:
Panel Member 2007-2009 NMRC Scientific Review Panel Singapore
Chair 2012-Current NUS-LSI Neurobiology Programme Steering Committee Singapore
Panel Member 2009-Current NMRC Local Review Panel Singapore
Steering Committee Member 2009-Current Singapore Graduate Program in Neuroscience Singapore

Publications

Author Title Journal Year Vol: Page
Li, L., Zhang C.W., P., Chen G.Y.J., Zhu, B., Y.W., Chai. C., Xu, Q., Tan, E.K., Kung, S.K.P., Lim, K.L.*, Yao, S.Q.*(*co-corresponding) A Two-Photon Small Molecule Enzymatic Probe for Specific and Sensitive Detection of MAOB Activity in Parkinson’s disease Models. Nature Communications 2014 13;5:3276
Haskin, J., Szargel, R., Shani, V., Mekies, L., Roth, R., Lim, G.G., Lim, K.L., Bandopadhyay, R., Wolosker, H., Engelender, S. AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson’s disease. HUM MOL GENET 2013 22 :2083-96
Ng, C.H., Guan, M.S.H., Koh, C., Ouyang, X, Yu, F., Tan, E.K., O’Neill, S., Zhang, X., Chung, J., Lim, K.L. AMP kinase activation mitigates dopaminergic dysfunction and mitochondrial abnormalities in Parkinson’s disease J NEUROSCI 2012 32:14311–14317
Lim, K.L. and Lim, G.G K63-linked ubiquitination and neurodegeneration NEUROBIOL DIS 2011 43, 9-16
Lee, JY, Nagano, Y, Taylor, J.P, Lim, K.L., Yao, TP Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation and HDAC6-dependent mitophagy J CELL BIOL 2010 189, 671-9
Ng, C.H., Mok, Z.X.S., Koh, C., Ouyang, X., Fivaz, M.L., Tan, E.K., Dawson, V.L., Dawson T.M., Yu, F., and Lim, K.L. Parkin Protects Against LRRK2 G2019S Mutant-induced Dopaminergic Neurodegeneration in Drosophila J NEUROSCI 2009 29, 11257-11262
Tan, M.M.J., Wong E.S.P, Pletnikova, O, Kirkpatrick, D.S., Ko, H., Ho, M.W.L., Tay, S.P., Troncoso, J., Gygi, S.P., Lee, M.K., Dawson, V.L., Dawson T.M., Lim, K.L. Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. HUM MOL GENET 2008 17, 431-439
Wang C., Lu, R., Ouyang X., Ho W.L.M., Chia, W., Yu, F., Lim, K.L. Drosophila Overexpressing Parkin missense mutants exhibits dopaminergic neuron degeneration and mitochondrial abnormalities. J NEUROSCI 2007 27, 8563-8570.
Von Coelln, R., Thomas, B., Andrabi, S.A., Lim, K.L., Savitt, J.M., Saffary, R., Stirling, W., Bruno, K., Hess, E.J., Lee, M.K., Dawson, V.L., Dawson T.M. Inclusion body formation and neurodegeneration are parkin-independent in a mouse model of alpha-synucleinopathy. J NEUROSCI 2006 26 3685-3696
Lim, K.L., Chew C.M.K., Tan, M.M. J., Wang C., Chung, K.K.K., Zhang, Y., Tanaka Y., Smith, W.L., Engelender, S., Ross, C.A., Dawson, V.L. and Dawson, T.M Parkin mediates non-classical, proteasomal-independent, ubiquitination of Synphilin-1: Implications for Lewy Body formation. J NEUROSCI 2005 25, 2002-2009
Von Coelln, R., Thomas, B., Savitt, J.M., Lim, K.L., Sasaki, M., Hess, E., Dawson, V.L. and Dawson, T.M. Loss of locus coeruleus neurons and reduced startle in parkin null mice PROC NAT ACAD SCI 2004 101, 10744-49
Pawlyk, A.C., Giasson, B.I., Perez, F.A., Sampathu, D.M., Lim, K.L., Dawson, V.L., Dawson, T.M., Palmiter, R., Trojanowski, J.Q. and Lee, V.M.Y. New monoclonal antibodies demonstrate biochemical variation of brain parkin with age. J BIOL CHEM 2003 278, 48120-8
Chung, K.K.K., Zhang, Y., Lim, K.L., Tanaka, Y., Huang, H., Gao, J., Ross, C.A., Dawson, V.L. and Dawson, T.M. Parkin ubiqutinates the ?-synuclein-interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson’s disease. NAT MED 2001 7, 1144-1150

Prizes/Awards

Description Year Organization/Country
Outstanding Mentor Award 2008 Science Mentorship Program, MOE/ Singapore
Poster Award (Corresponding Author) 2008 Gordon Research Conference on Autophagy/ United States
Khoo Discovery Award 2008 Khoo Teck Puat Foundation/Duke-NUS/ Singapore

Patents

Patent Title Patent Number Year Awarded Patent Country
Novel Protein Tyrosine Phosphatase Inhibitor. 7199121 2007 United States

International Editorship/Advisorship

Description From Year To Year Organisation/Country
Academic Editor 2012 Current PLoS One/ United States