Dr Chia, Brian - Profile

UserID: 6449
Email: cschia@etc.a-star.edu.sg
Organization: Experimental Therapeutics Centre (ETC), A*STAR
Department : Peptide Chemistry
Tel : 64070348
URL : www.etc.a-star.edu.sg
My Page
Keywords :
antibacterial
anti-bacterial
antibiotics
antiviral
anti-viral
chemistry
Chikungunya
Dengue
drug discovery
enterovirus
ev71
GRP78
HFMD
infectious disease
medicine
MRSA
peptide
peptidomimetic
pharmaceutical sciences
picornavirus
protease inhibitors
virology
bacteriology

Last Login Date : 06/02/2018 15:00:17
Last Updated Date : 31/01/2018 17:04:52

Summary :
Research Area : Bacteriology
Biological Sciences
Cancer/Oncology
Chemistry
Clinical Pharmacology and Therapeutics
Infectious Diseases
Medical Biochemistry: Proteins and Peptides
Mycology
Pharmaceutical Sciences and Pharmacy
Virology
Other: peptides, peptidomimetics, antivirals, antibacterials, antifungals, antibiotics, anti-cancer
Education :
PhD 2000 University of Adelaide Australia
Others 1997 University of Adelaide Australia
Bachelor 1996 University of Adelaide Australia
Scientific Appointment :
Group Leader 2007-Current Experimental Therapeutics Centre Singapore

Employment History

Designation Duration Organization Country
Group Leader (Grade 9) 2016-Current Experimental Therapeutics Centre Singapore
Group Leader (Grade 8) 2011-2016 Experimental Therapeutics Centre Singapore
Group Leader (Grade 7) 2007-2011 Experimental Therapeutics Centre Singapore
Research Scientist 2005-2007 IMCB Singapore
Research Scientist 2002-2005 DSO National Laboratories Singapore
Post-Doctoral Fellow 2000-2002 Cambridge University United Kingdom

Publications

Author Title Journal Year Vol: Page
Teo SW, Yong YE, Ng SMS, Ng FM, Teo JWP, Jureen R, Hill J, Chia CSB. Identification of an ultra-short peptide with potent Pseudomonas aeruginosa activity for development as a topical antibacterial agent. International Journal of Peptide Research and Therapeutics 2018 DOI: 10.1007/s10989-
Ng SMS, Sioson JSP, Yap JM, Ng FM, Ching HSV, Teo JWP, Jureen R, Hill J, Chia CSB. Repurposing Zidovudine in combination with Tigecycline for treating carbapenem-resistant Enterobacteriaceae infections. European Journal of Clinical Microbiology and Infectious Diseases 2018 37,141–148
Ng SMS, Ching HSV, Xu GF, Ng FM, Ong EHQ, Lau QY, Jureen R, Hill J, Chia CSB. Screening for a potent antibacterial peptide to treat mupirocin-resistant MRSA skin infections. International Journal of Peptide Research and Therapeutics 2017 23, 481–491
Ng SMS, Teo SW, Yong YE, Ng FM, Lau QY, Jureen R, Hill J, Chia CSB. Preliminary investigations into developing all-D Omiganan for treating mupirocin-resistant MRSA skin infections. Chemical Biology and Drug Design 2017 90, 1155–1160
Ng SMS, Yap YYA, Cheong JWD, Ng FM, Lau QY, Barkham T, Teo WPJ, Hill J, Chia CSB. Antifungal peptides: a potential new class of antifungals for treating vulvovaginal candidiasis caused by fluconazole-resistant Candida albicans. Journal of Peptide Science 2017 23, 215–221
Ang, M.J.Y., Lau, Q.Y., Ng, F.M., Then, S.W., Poulsen, A., Tan, Y.W., Keller, T.H., Hill, J., Chu, J.J.H., Chia, C.S.B. Peptidomimetic ethyl propenoate covalent inhibitors of the Enterovirus 71 3C protease: a P2 – P4 study. Journal of Enzyme Inhibition and Medicinal Chemistry 2016 31, 332–339
Ang MJY, Lim HA, Poulsen A, Wee JL, Ng FM, Joy J, Hill J, Chia CSB. Miniature bovine pancreatic trypsin inhibitor (m-BPTIs) of the West Nile virus NS2B-NS3 protease. Journal of Enzyme Inhibition and Medicinal Chemistry 2016 31, 194-200
Tan, Y.W., Ang, M.J.Y., Lau, Q.Y., Poulsen, A., Ng, F.M., Then, S.W., Peng, J., Hill, J., Hong, W.J., Chia, C.S.B., Chu, J.J.H. Antiviral activities of peptide-based covalent inhibitors of the Enterovirus 71 3C protease. Scientific Reports 2016 6,33663
Chen, G.-Y., Ng, F.M., Tan, Y.Y.W., Poulsen, A., Seetoh, W.G., Lin, G., Kang, C.B., Then, S.W., Ahmad, N.H., Wong, Y.L., Ng, H.-Q., Chia, C.S.B., Lau, Q.Y., Hill, J., Hung, A.W., Keller, T.H. Application of fragment-based drug discovery against DNA Gyrase B. ChemPlusChem 2015 80, 1250–1254
Lau, Q.Y., Choo, X.Y., Lim, Z.X., Kong, X.N., Ng, F.M., Ang, M.J.Y., Hill, J., Chia, C.S.B. A head-to-head comparison of the antimicrobial activities of 30 ultra-short antimicrobial peptides against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. International Journal of Peptide Research and Therapeutics. International Journal of Peptide Research and Therapeutics 2015 21, 21–28
Moreira, W., Ngan, G.J.Y., Low, J.L., Poulsen, A., Chia, C.S.B., Ang, J.Y., Yap, A., Fulwood, J., Lakshmanan, U., Lim, J., Ting, T., Flotow, H., Raju, R.M., Rubin, E.J., Dick, T. A target mechanism-based whole cell screen identifies Bortezomib as an inhibitor of caseinolytic protease in mycobacteria. mBio 2015 e00253–15
Chu, J.J.H., Lee, R.C.H., Ang, M.J.Y., Wang, W.-L., Lim, H.A., Wee, J.L.K., Joy, J., Hill, J., Chia, C.S.B. Antiviral activities of 15 Dengue NS2B-NS3 protease inhibitors using a human cell-based viral quantification assay. Antiviral Research 2015 118, 68–74
Lau, Q.Y., Tan, Y.Y.F., Goh, V.C.C., Lee, D.J.Q., Ng, F.M., Ong, E.H.Q., Hill, J., Chia, C.S.B. An FDA-drug library screen for compounds with bioactivities against meticillin-resistant Staphylococcus aureus (MRSA). Antibiotics 2015 4, 424–434
Lau, Q.Y., Ng, F.M., Cheong, J.W.D., Yap, Y.Y.A., Tan, Y.Y.F., Jureen, R., Hill, J., Chia, C.S.B. Discovery of an ultra-short linear antibacterial tetrapeptide with anti-MRSA activity from a structure-activity relationship study. European Journal of Medicinal Chemistry 2015 105, 138–144
Pobbati, A.V., Han, X., Hung, A.W., Seetoh W.G., Huda, N., Chen, G.-Y., Kang, C.B., Chia, C.S.B., Luo, X., Hong, W., Poulsen, A. Targeting the central pocket in human transcription factor TEAD as a potential cancer therapeutic strategy. Structure 2015 23, 1–11
Ang, M.J.Y., Li, Z., Lim, H.A., Ng, F.M., Then, S.W., Wee, J.L.K., Joy, J., Hill, J., Chia, C.S.B. A P2 and P3 substrate specificity comparison between the Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides. Peptides, An International Journal 2014 52, 49–52
Kim, Y.M., Gayen, S., Kang, C.B., Joy, J., Huang, Q., Wee, L.K., Ang, M.J.Y., Lim, H.A., Hung, A.W., Li, R., Noble, C.G., Lee, L.T., Yip, A., Wang, Q.Y., Chia, C.S.B., Hill, J., Shi, P.-Y., Keller, T. H. NMR analysis of a novel enzymatically-active unlinked Dengue NS2B-NS3 protease complex. Journal of Biological Chemistry 2013 288, 12891–12900
Lim, H.A., Ang, M.J.Y., Joy, J., Poulsen, A., Wu, W., Ching, S.C., Hill, J., Chia, C.S.B. Novel agmatine dipeptide inhibitors against the West Nile virus NS2B/NS3 protease: A P3 and N-cap optimization study. European Journal of Medicinal Chemistry 2013 62, 199–205
Ang, M.J.Y., Yong, G.H.J., Poulsen, A., Then, S.W., Li, Z. Joy, J., Hill, J., Chia, C.S.B. Substrate-based peptidomimetic inhibitors of the Murray Valley encephalitis virus NS2B/NS3 serine protease: a P1-P4 SAR study. European Journal of Medicinal Chemistry 2013 68, 72–80
Kang, C.B., Gayen, S., Wang, W.-L., Severin, R., Chen, A.S., Lim, H.A., Chia, C.S.B., Schüller, A., Doan, N.P., Poulsen, A., Hill, J., Vasudevan, S.G., Keller, T.H. Exploring the binding of peptidic West Nile Virus NS2B-NS3 protease inhibitors by NMR. Antiviral Research 2013 97, 137–144
Lim, H.A., Tan, L.T., Chia, C.S.B. Exploring solution-phase cyclization and sulfamyl safety-catch resin strategies for the total synthesis of the marine antimicrobial cyclic tetrapeptide cyclo(GSPE). International Journal of Peptide Research and Therapeutics 2013 19, 25–31
Ang, M.J.Y., Lim, H.A., Chia, C.S.B. Solid-phase synthesis of a library of C-terminal agmatine dipeptides using a backbone amide linker (BAL) strategy. Tetrahedron Letters 2012 53, 5511–5514
Lim, H.A., Kang, C.B., Chia, C.S.B. Solid-phase synthesis and NMR structural studies of the marine antibacterial cyclic tetrapeptide: cyclo[GSPE]. International Journal of Peptide Research and Therapeutics 2011 16, 145–152
Brown, C.J., Dastidar, S.G., Quah, S.T., Lim, H.A., Chia, C.S.B., Verma, C.S. C-terminal substitution of MDM2 interacting peptides modulates binding affinity by distinctive mechanisms. PLOS One 2011 6(8), e24122
Lim, H.A., Ong, A, Chia, C.S.B. Towards a cyclic tetrapeptide library for bioactivity screening. Peptide Science 2011 47, 216
Lim, H.A., Joy, J., Hill, J., Chia, C.S.B. Novel agmatine and agmatine-like peptidomimetic inhibitors of the West Nile virus NS2B/NS3 serine protease. European Journal of Medicinal Chemistry 2011 46, 3130–3134
Chia, C.S.B., Gong, Y.J., Bowie, J.H., Zuegg, J., Cooper, M.A. Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin and maculatin. Biopolymers 2011 96, 147–157
Brown, C.J., Lim, J.J., Leonard, T., Lim, H.A., Chia, C.S.B., Verma, C.S., Lane, D.P. Stabilizing the eIF4G1 alpha-helix increases its binding affinity with eIF4E: implications for peptidomimetic design strategies. Journal of Molecular Biology 2011 405, 736–753
Schüller, A., Yin, Z., Chia, C.S.B., Doan, N.P., Kim, H.-K., Shang, L., Loh, T.P., Hill, J., Vasudevan, S.G. Tripeptide inhibitors of the Dengue and West Nile virus NS2B/NS3 protease. Antiviral Research 2011 92, 96–101

Prizes/Awards

Description Year Organization/Country
A*STAR 10-year long service award 2017 Experimental Therapeutics Centre/ Singapore
Promotion in Scientific Grade 2016 Experimental Therapeutics Centre/ Singapore
$1.1 million 3-year CBRG grant by NMRC to develop peptide-based anticancer therapeutics in collaboration with Department of Biological Science, NUS 2014 Experimental Therapeutics Centre / Singapore
$1 million 3-year IAF grant by BMRC to develop antivirals for HFMD in collaboration with IMCB 2013 Experimental Therapeutics Centre/ Singapore
A*STAR 5-year long service award 2012 Experimental Therapeutics Centre/ Singapore
Promotion in Scientific Grade 2011 Experimental Therapeutics Centre/ Singapore
Promotion to Group Leader in ETC 2007 Experimental Therapeutics Centre / Singapore
British Biotechnology and Biological Science Research Council Award 2000 Cambridge University/ United Kingdom
Overseas Postgraduate Research Scholarship 1997 The University of Adelaide/ Australia
Overseas Student Merit Scholarship 1996 The University of Adelaide / Australia
Silver Award in Organic Chemistry 1996 The University of Adelaide/ Australia

Patents

Patent Title Patent Number Year Awarded Patent Country
Therapeutic SALL4 peptides. WO 2017/190032 2017 International
Antimicrobial peptidomimetics. SG10201706251Q 2017 Singapore
EIF4E binding peptides. US 9533023 2017 United States
Antifungal and antibacterial peptides. GB 1604106.3 2016 United Kingdom
EIF4E binding peptides. EP 2569327 2016 United Kingdom
Compounds for treatment of cancer and epigenetics. PCT/SG2016/050499 2016 International
Therapeutic SALL4 peptides. US 62/329010 2016 United States
Bortezomib as an inhibitor of Mycobacterial caseinolytic protease (Clp) for the treatment of tuberculosis. US 62/113067 2015 United States
Bortezomib as an inhibitor of Mycobacterial caseinolytic protease (Clp) for the treatment of tuberculosis. WO 2015/112093 2015 International
Antimicrobial peptidomimetics. WO 2015/112093A2 2015 International
EIF4E binding peptides. US 9018348 2015 United States
EIF4E binding peptides. EC 11775390.5 2015 International
Cyclic peptide serine protease inhibitors. GB 1513019.8 2015 United Kingdom
Antimicrobial peptidomimetics. GB 2522412 2014 United Kingdom
EIF4E binding peptides. WO 2011/136744A1 2011 International

Collaborations

Collapse Company
Project Institution/Organization Name Description From Year To Year
see Description see Description Click Hospitals, Industry, University and RI icons above 2009 Current
Collapse Hospital
Project Institution/Organization Name Description From Year To Year
Antibacterials against MRSA NUH Developing new antibiotics for MRSA skin infections. 2014 Current
Antivirals against Dengue Duke-NUS Developing antivirals against the Dengue virus. 2009 2011
Collapse Industry
Project Institution/Organization Name Description From Year To Year
Antivirals against Dengue Novartis Institute for Tropical Diseases Developing antivirals against the Dengue virus. 2011 2012
Collapse University
Project Institution/Organization Name Description From Year To Year
Anticancer therapeutics NUS (DBS) Anticancer peptidomimetics targeting GRP78 2014 Current
Antivirals against Dengue NUS (Microbiology) Developing antivirals against Dengue viral infections. 2014 2015
Antivirals against Chikungunya NUS (Microbiology) Developing antivirals against Chikungunya viral infections. 2013 2014
Antivirals against ev71 NUS (Microbiology) Developing antivirals against enterovirus 71 for the treatment of Hand, foot and mouth disease (HFMD). 2012 2014
Collapse RI
Project Institution/Organization Name Description From Year To Year
Anticancer therapeutics Cancer Science Institute Anticancer peptidomimetics targeting RBBP4 2014 Current
Stapled peptides p53 Laboratory Design cell-permeable stapled peptides that inhibit the p53-MDM2 interaction. 2009 2011
EIF4 anti-cancer peptides IMCB Developing novel peptide modulators of the eukaryotic initiation factor epsilon 4 (EIF4) cell transformation and growth pathway. 2007 2010

Grant

Project Title
Anticancer peptidomimetics [Cooperative Basic Research Grant (CBRG), National Medical Research Council (NMRC)]
Antivirals against enterovirus71 [Industrial Alignment Fund (IAF Cat 3)]