Prof Lane, David - Profile

UserID: 6349
Organization: p53 Laboratory (p53Lab), A*STAR
My Page
Keywords :
breast cancer
tumour suppressor

Last Login Date : 04/07/2016 15:19:50
Last Updated Date : 04/07/2016 15:21:21

Summary :
Education :
PhD 1976 University College London
Bachelor 1973 University College London
Scientific Appointment :
Chairman 2012-Current Chugai Pharmabody Research Pte Ltd Singapore
Chief Scientist 2009-Current A*STAR Singapore
Personal Chair in Molecular Oncology 1990-Current University of Dundee
Chief Scientist 2007-2011 Cancer Research UK
Chairman 2007-2009 Biomedical Research Council Singapore
Chief Executive Officer 2007-2009 Experimental Therapeutics Centre Singapore
Executive Director 2004-2007 Institute of Molecular and Cell Biology Singapore
Principal Scientist 1988-1990 Imperial Cancer Research Fund
Senior Staff Scientist 1985-1988 Imperial Cancer Research Fund
Lecturer 1981-1985 Imperial College of Science & Technology
Robertson Reserch Fellow 1978-1980 Cold Spring Harbor Laboratories United States
Postdoctoral Fellow 1976-1977 Imperial Cancer Research Fund


Author Title Journal Year Vol: Page
Mondal, A.M., Horikawa, I., Pine, S.R., Fujita, K., Morgan, K.M., Vera, E., Mazur, S.J., Appella, E., Vojtesek, B., Blasco, M.A., Lane, D.P., Harris, C.C. p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes. J CLIN INVEST 2013 123(12):5247-57.
Guo L, Liew HP, Camus S, Goh AM, Chee LL, Lunny DP, Lane EB, Lane DP. Ionising radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafish. ONCOGENE 2013 32(34):4009-16
Tao, T., Shi, H., Guan, Y., Huang, D., Chen, Y., Lane, D.P., Chen, J., Peng, J. Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation. Cell Res. 2013 23(5):620-34.
Wong, J.S., Warbrick, E., Vojtesk, B., Hill, J., Lane, D.P. Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth. Oncotarget. 2013 4(7):1019-36.
Coffill, C.R., Muller, P.A., Oh, H.K., Neo, S.P., Hogue, K.A., Cheok, C.F., Vousden, K.H., Lane, D.P., Blackstock, W.P., Gunaratne, J. Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. EMBO Rep 2012  
Muller, P.A., Trinidad, A.G., Timpson, P., Morton, J.P., Zanivan, S., van den Berghe, P.V., Nixon, C., Karim, S.A., Caswell, P.T., Noll, J.E., Coffill, C.R., Lane, D.P., Sansom, O.J., Neilsen, P.M., Norman, J.C., Vousden, K.H. Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. ONCOGENE 2012  
Goh AM, Lim CY, Chiam PC, Li L, Mann MB, Mann KM, Menendez S, Lane DP. Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity. PROC NAT ACAD SCI USA 2012 109(5):1685-90.
Dastidar, S.G., Raghunathan, D., Nicholson, J., Hupp, T.R., Lane, D.P. and Verma, C.S. Chemical states of the N-terminal "lid" of MDM2 regulate p53 binding: simulations reveal complexities of modulation. Cell Cycle 2011 10(1):82-9.
Lane, D.P., Madhumalar, A., Lee, A.P., Tay, B.H., Verma, C., Brenner, S, and Venkatesh B. Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish. Cell Cycle 2011 10(24) 4272-9.
Lane, D.P., Cheok, C.F., Brown, C., Madhumalar, A., Ghadessy, F.J. and Verma, C. Mdm2 and p53 are highly conserved from placozoans to man. Cell Cycle 2010 9(3):540-547.
See HY, Lane DP. A Novel Unstructured Scaffold Based on 4EBP1 Enables the Functional Display of a Wide Range of Bioactive Peptides J MOL BIOL 2010 404(5):819-31
Cheok CF, Kua N, Kaldis P, Lane DP. Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53 CELL DEATH DIFFER 2010  
Brown CJ, Dastidar SG, See HY, Coomber DW, Ortiz-Lombardía M, Verma C, Lane DP. Rational Design and Biophysical Characterization of Thioredoxin-Based Aptamers: Insights into Peptide Grafting. J MOL BIOL 2009 Article in Press
Chen J, Ng SM, Chang C, Zhang Z, Bourdon JC, Lane DP, Peng J. p53 isoform delta113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish GENE DEV 2009 23(3): 278-290
Brown CJ, Verma CS, Walkinshaw MD, Lane DP. Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site Cell Cycle 2009 8:12, 1905-1911
Wan KF, Wang S, Brown CJ, Yu VC, Entzeroth M, Lane DP, Lee MA. Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-XL Cell Cycle 2009 8(23):3943-52
Lain S, Hollick JJ, Campbell J, Staples OD, Higgins M, Aoubala M, McCarthy A, Appleyard V, Murray KE, Baker L, Thompson A, Mathers J, Holland SJ, Stark MJ, Pass G, Woods J, Lane DP, Westwood NJ. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator CANCER CELL 2008 13(5):454-63
Lee KC, Goh WL, Xu M, Kua N, Lunny D, Wong JS, Coomber D, Vojtesek B, Lane EB, Lane DP. Detection of the p53 response in zebrafish embryos using new monoclonal antibodies ONCOGENE 2008 27 (5) 629-40
Dey A, Wong ET, Cheok CF, Tergaonkar V, Lane DP. R-Roscovitine simultaneously targets both the p53 and NF-kappaB pathways and causes potentiation of apoptosis: implications in cancer therapy CELL DEATH DIFFER 2008 15(2):263-73
Stevenson LF, Sparks A, Allende-Vega N, Xirodimas DP, Lane DP, Saville MK. The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2 EMBO J 2007 26(4):976-86
Cheok CF, Dey A, Lane DP. Cyclin-dependent kinase inhibitors sensitize tumor cells to nutlin-induced apoptosis: a potent drug combination Mol Cancer Res 2007 5(11):1133-45
Kontopidis G, Wu SY, Zheleva DI, Taylor P, McInnes C, Lane DP, Fischer PM, Walkinshaw MD. From the Cover: Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design P NATL ACAD SCI USA 2005 102(6):1871-6
Chen J, Ruan H, Ng SM, Gao C, Soo HM, Wu W, Zhang Z, Wen Z, Lane DP, Peng J. Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish GENE DEV 2005 19(23):2900-11
Bourdon JC, Fernandes K, Murray-Zmijewski F, Liu G, Diot A, Xirodimas DP, Saville MK, Lane DP. p53 isoforms can regulate p53 transcriptional activity. GENE DEV 2005 19(18):2122-37
Xirodimas, D., Saville, M. K., Bourdon, J.C., Hay, R.T., Lane. D.P. Mdm2-Mediated NEDD8 Conjugation of p53 Inhibits its Transcriptional Activity. CELL 2004 118, 83-97
Bottger A., Bottger V., Sparks A., Liu W.L., Howard S., and D.P.Lane Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo CURR BIOL 1997 7(11) 860-869
Hupp,T.R., Sparks,A and Lane D.P. Small peptides activate the latent sequence specific DNA binding function of p53 CELL 1995 83, 237-245
Lu,X. & Lane DP. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosone instability syndromes? CELL 1993 75, 765-778
Hall,P.A., McKee,P.H., Menage, H du P., Dover,R., Lane,D.P. High levels of p53 protein in UV irradiated normal human skin ONCOGENE 1993 8, 203-207
Hupp, T.R., Meek, D.W., Midgley,C.A. and Lane,D.P. Regulation of the DNA binding function of p53 CELL 1992 71, 875-886
Lane,D.P. Cancer - p53, Guardian of the Genome NATURE 1992 358, 15-16
Bártek J, Bártková J, Vojtesek B, Stasková Z, Lukás J, Rejthar A, Kovarík J, Midgley CA, Gannon JV, Lane DP. Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies ONCOGENE 1991 6, 1699-1703
Iggo,R. Gatter K.G. Bartek,J., Lane,D., and Harris A.L. Increased expression of mutant forms of the p53 oncogene in primary lung cancer LANCET 1990 335, 675-679
Yewdell, J.W., Gannon, J.V. and Lane, D.P. Monoclonal antibody analysis of p53 expression in normal and transformed cells J VIROL 1986 59. 444-452
Lane, D.P. and Crawford, L.V. SV40 T antigen is bound to a host protein in V40 transformed cells NATURE 1979 278, 261-263
Please see for a list of Publications and my accomplished PhD students. Please see for a list of Publications and my accomplished PhD students.      


Description Year Organization/Country
Extraordinary Professor to the TEFAF Oncology Chair 2011 TEFAF/ Netherlands
Datta Medal 2009 Federation of European Biochemical Societies / International
Doctor Honoris Causa 2007 University Paul Sabatier/ France
Gregor Mendel Memorial Medal 2007 Brno/ Czech Republic
David Hungerford Lecture Medal 2007 Bangalore/ India
Inserm Award 2006 INSERM/ France
Int. Agency for Res. on Cancer (IARC) Medal 2005 IARC/ France
Sergio Lombroso Award in Cancer Research 2005 Weizmann Institute of Science/ Israel
Anthony Dipple Carcinogenesis Award 2004 EACR/ International
Paul Ehrlich Prize 1998 The Paul Ehrlich Foundation/ Germany
Yvette Mayent Prize 1995 Curie Institute/ France
Black Prize 1995 Thomas Jefferson University/ United States
Meyenburg Prize 1995 Meyenburg Foundation/ Germany
Medal of the Swedish Society of Oncology 1994 Swedish Society of Oncology/ Sweden
Charles Rodolphe Brupbacher Prize 1993 Charles Rodolphe Brupbacher Foundation/ Switzerland
Joseph Steiner Prize 1993 Joseph Steiner Cancer Research Foundation/ Switzerland
Howard Hughes International Scholar Award 1993 Howard Hughes Medical Institute/ United States
Member of European Molecular Biology Organisation 1990 European Molecular Biology Organisation / International