Dr Xu, Shengli - Profile

UserID: 4884
Email: xu_shengli@bti.a-star.edu.sg
Organization: Bioprocessing Technology Institute (BTI), A*STAR
Affiliated Organizations : National University of Singapore (NUS)


Tel : 64070026
My Page
Keywords :
B lymphocyte differentiation and malignancy
Signal transduction mediated by immune receptors

Last Login Date : 02/11/2010 17:07:25
Last Updated Date : 02/11/2010 17:08:20

Summary :
Research Area : Cellular Immunology
Immunology: Others
Tumour Immunology
Education :
PhD 2003 National University of Singapore Singapore
Master 1994 Nankai University China
Bachelor 1991 Nankai University China
Scientific Appointment :
Adjunct Assistant Professor 2010-Current Department of Physiology, NUS Singapore
Research Scientist 2008-Current Bioprocessing Technology Institute Singapore
Senior Research Fellow 2006-2008 Singapore Immunology Network Singapore
Research Associate 2006-2006 Institute of Molecular and Cell Biology Singapore
Research Fellow 2003-2006 Institute of Molecular and Cell Biology Singapore

Publications

Author Title Journal Year Vol: Page
Huo, J., Xu, S., Lam, K. P. FAS apoptosis inhibitory molecule regulates T cell receptor-mediated apoptosis of thymocytes by modulating AKT activation and NUR77 expression. J BIOL CHEM 2010 11827-37
Xu, S.; Huo, J.; Gunawan, M.; Su, I. H.; Lam, K. P. Activated dectin-1 localizes to lipid raft microdomains for signaling and activation of phagocytosis and cytokine production in dendritic cells. J BIOL CHEM 2009 22005-11
Xu,S.; Huo,J.; Lee,K.G.; Kurosaki,T.; Lam,K.P. Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells J BIOL CHEM 2009 284(11): 7038-7046
Huo,J.; Xu,S.; Guo,K.; Zeng,Q.; Lam,K.P. Genetic deletion of faim reveals its role in modulating c-FLIP expression during CD95-mediated apoptosis of lymphocytes and hepatocytes CELL DEATH DIFFER 2009 16(7): 1062-1070
Benson M.J., Dillon S.R., Geha R.S., Xu S., Lam, K-P and Noelle R.J. The roles of BAFF and APRIL in sustaining long-lived humoral immunity. J IMMUNOL 2008 180(6): 3655-3659
Lee, K.G., Xu, S and Lam, K-P Bruton's tyrosine kinase separately regulates NFkappaB p65RelA activation and cytokine IL-10/IL-12 production in TLR 9-stimulated B cells J BIOL CHEM 2008 283(17): 11189-11198
Xu, S., Lee,K.G., Huo, J., Kurosaki, T., Lam, K-P Combined deficiencies in Bruton’s Tyrosine Kinase and Phospholipase Cgamma2 arrest B cell development at a pre-BCR-positive stage. BLOOD 2007 109(8) 3377-3384
Ng, C.H., Xu, S., Lam, K-P Dok-3 plays a non-redundant role in negative regulation of B cell activation. BLOOD 2007 110(1) 259-266
Xu, S., Huo, J., Chew WK, Hikida, M., Kurosaki, T and Lam, K-P PLC?2 dosage is critical for B cell development in the absence of adaptor protein BLNK J IMMUNOL 2006 176(8): 4690-4698
Ng, L.G.; Ng, C.H.; ; Woehl, B.; Sutherland, A.P.; Huo, J.; Xu, S.; Mackay, F.; Lam, K-P. BAFF costimulation of Toll-like receptor-activated B-1 cells. EUR J IMMUNOL 2006 36(7): 1837-1846
Castigli, E, Wilson, SA, Scott, S, Dedeoglu F, Xu, S, Lam, K-P, Bram, RJ, Jabara, H, Geha, RS. TACI and BAFF-R mediate isotype switching in B cells J EXP MED 2005 201(1):35-39
Xu, S., Huo, J., Tan, J.E., Lam, K-P Cbp deficiency alters Csk localization in lipid rafts but does not affect T-cell development. MOL CELL BIOL 2005 25(19): 8486-8495
Novonrantseva T, Xu S, Tan, J.E. –L, Maruyama M, Schwers S, Pelanda R, Rajewsky K, Lam, K, -P. Stochastic Pairing of Immunoglobulin Heavy Chain and Light Chain Frequently Generates B Cell Antigen Receptors That Are Subject to Editing in Vivo. INT IMMUNOL 2005 17(4): 343-350
Xu, S., and Lam, K.-P Delayed cellular maturation and decreased immunoglobulin k light chain production in immature B lymphocytes lacking B cell linker protein. J EXP MED 2002 196(2):197-206
Xu, S., and Lam, K. -P B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses. MOL CELL BIOL 2001 21 (12): 4067-74
Tan, J. E. -L., Wong, S. -C., Gan, S. K. -E., Xu, S., and Lam, K. -P The adaptor protein BLNK is required for B cell antigen receptor-induced activation of nuclear factor-kB and cell cycle entry and survival of B lymphocytes. J BIOL CHEM 2001 276(23): 20055-20063
Xu, S., Wong, S.-C., and Lam, K.-P B cell linker protein is dispensable for the allelic exclusion of immunoglobulin heavy chain locus but required for the persistence of CD5+ B cells J IMMUNOL 2000 165(8): 4153-4157
Xu, S., Tan, J. E.-L., Wong, E. P.-Y., Manickam, A., Ponniah, S. and Lam, K.-P B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice INT IMMUNOL 2000 12(3): 397-404