Dr Ang, Cher Siang, Peter - Profile

UserID: 450
Email: peter_ang@oncocare.sg
Organization: National Cancer Centre, Singapore (NCCS)
Department : Medical Oncology
Affiliated Organizations : OncoCare Cancer Centre


URL : http://www.oncocare.sg
My Page
Keywords :
ovarian cancer
brain cancer
BRCA1
BRCA2
breast cancer
chemotherapy
colorectal cancer
endometrial cancer
Her2
herceptin
hereditary cancer
HNPCC
mammogram
metastatic breast cancer
MLH1
MSH2
p53
pancreatic cancer
stage 4 breast cancer
stomach cancer.
triple negative breast cancer

Last Login Date : 24/08/2017 08:55:29
Last Updated Date : 24/08/2017 09:07:14

Summary :
Research Area : Cancer/Oncology
Clinical Pharmacology and Therapeutics
Health Sciences
Other: Cancer genetics
Education :
Dr 1997 National University of Singapore Singapore
Dr 1997 Royal College of Medicine (UK) International
Dr 1991 National University of Singapore Singapore
Scientific Appointment :
Senior Consultant 2007-Current OncoCare Cancer Centre International
Senior Consultant 2003-2007 National Cancer Center, Singapore International
Associate consultant 2001-2003 National Cancer Center, Singapore International
Fellow 2000-2001 Dana-Farber Cancer Institute, Boston, USA International
Principal Investigator 2000-2000 Human and Molecular Genetics Research programme International
Registrar 1998-2000 National Cancer Center, Singapore International
Medical Officer 1995-1997 Singapore General Hospital International
Medical Officer 1993-1995 Singapore Arm Forces Medical Center International
Medical Officer 1992-1993 Tan Tock Seng Hospital International
Singapore Based Committee:
Director 2004-2007 Cancer Education, NCC Singapore
Chairman 2004-2007 Singhealth Public Education Service Developmt Line Singapore
Member 2003-2007 Singhealth Breast Cancer Health Development Plan Singapore
Program Leader 2002-2007 Breast Cancer Workgroup, NCC Singapore
Co-chair 2005-2005 Breast Cancer Awareness Month Singapore
Member 2005-2005 Bioethics Advisory Consultation on Genetic testing Singapore

Publications

Author Title Journal Year Vol: Page
Lal S, Sutiman N, Ooi LL, Wong ZW, Wong NS, Ang PCS, Chowbay B Pharmacogenetics of ABCB5, ABCC5 and RLIP76 and doxorubicin pharmacokinetics in Asian breast cancer patients Pharmacogenomics J 2017 Jul;17(4):337-343
Chan CHT, Munusamy P, Loke SY, Koh GL, Wong ESY, Law HY, Yoon CS, Tan MH, Yap YS, Ang P, Lee ASG Identification of Novel Breast Cancer Risk Loci CANCER RES 2017 pii: can res.0992
Lim JS, Sutiman N, Muerdter TE, Singh O, Cheung YB, Ng RC, Yap YS, Wong NS, Ang PC, Dent R, Schroth W, Schwab M, Chowbay B Association of CYP2C19*2 and associated haplotypes with lower norendoxifen concentrations in tamoxifen-treated Asian breast cancer patients BRIT J CLIN PHARMACO 2016 Jun;81(6):1142-
Sutiman N, Lim JS, Muerdter TE, Singh O, Cheung YB, Ng RC, Yap YS, Wong NS, Ang PC, Dent R, Schroth W, Schwab M, Khor CC, Chowbay B Pharmacogenetics of UGT1A4, UGT2B7 and UGT2B15 and Their Influence on Tamoxifen Disposition in Asian Breast Cancer Patients CLIN PHARMACOKINET 2016 Oct;55(10):1239-50
E S Y Wong, S Shekar, M Met-Domestici, C Chan, M Sze, Y S Yap, S G Rozen, M Tan, P Ang, J Ngeow, A S G Lee. Inherited breast cancer predisposition in Asians: multigene panel testing outcomes from Singapore. npj Genomic Medicine 1 2016 vol 1, number 15003
Edward S. Y. Wong, Sandhya Shekar,1Claire H. T. Chan, Lewis Z. Hong,, Suk-Yean Poon, Toomas Silla, Clarabelle Lin, Vikrant Kumar, Sonia Davila, Mathijs Voorhoeve, Aye Aye Thike, Gay Hui Ho, Yoon Sim Yap, Puay Hoon Tan, Min-Han Tan, Peter Ang, and Ann S. G. Lee Predictive Factors for BRCA1 and BRCA2 Genetic Testing in an Asian Clinic-Based Population PLoS ONE 2015 10(7): e0134408.
Edward Wong, Yoon Sim Yap, Ying Ying Cheng, Delia Chua, Lewis Zuocheng Hong, William F. Burkholder, Gay Hui Ho, Min Han Tan, Peter Ang, and Ann S.G. Lee Mutations in the CBL gene among breast cancer patients in an Asian clinic-based population CANCER RES 2014 2014;74(19 Suppl):Ab
Lee AS, Ang P Breast-cancer risk in families with mutations in PALB2 NEW ENGL J MED 2014 371(17):1650-1.
Chay WY, Ong WS, Tan PH, Jie Leo NQ, Ho GH, Wong CS, Chia KS, Chow KY, Tan M, Ang P Validation of the Gail model for predicting individual breast cancer risk in a prospective nationwide study of 28,104 Singapore women Breast Cancer Res 2012 Jan 30;14(1):R19
Chan M, Ji SM, Yeo ZX, Gan L, Yap E, Yap YS, Ng R, Tan PH, Ho GH, Ang P, Lee AS Development of a next-generation sequencing method for BRCA mutation screening: a comparison between a high-throughput and a benchtop platform. J Mol Diagn 2012 Nov;14(6):602-12
Chan M, Ji SM, Liaw CS, Yap YS, Law HY, Yoon CS, Wong CY, Yong WS, Wong NS, Ng R, Ong KW, Madhukumar P, Oey CL, Tan PH, Li HH, Ang P, Ho GH, Lee AS Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population. BREAST CANCER RES TR 2012 Nov;136(1):209-20
Yeo ZX, Chan M, Yap YS, Ang P, Rozen S, Lee AS Improving indel detection specificity of the Ion Torrent PGM benchtop sequencer. PLoS ONE 2012 2012;7(9):e45798
Maurice Chan, Shen Mo Ji, Chiew Suan Liaw, Yoon Sim Yap, Hai Yang Law, Chui Sheun Yoon, Chow Yin Wong, Kong Wee Ong, Preetha Madhukumar, Nan Soon Wong, Raymond Ng, Wei Sean Yong, Hui Hua Li, Puay Hoon Tan, Gay Hui Ho, Peter Ang, and Ann SG Lee Evaluation of breast cancer susceptibility loci in Chinese women from Singapore CANCER RES 2012 72(8 Suppl):Abstract
Wong NS, Seah EZh, Wang LZ, Yeo WL, Yap HL, Chuah B, Lim YW, Ang PC, Tai BC, Lim R, Goh BC, Lee SC Impact of UDP-gluconoryltransferase 2B17 genotype on vorinostat metabolism and clinical outcomes in Asian women with breast cancer Pharmacogenet Genomics 2011 Nov;21(11):760-8.
Chan M, Chan MW, Loh TW, Law HY, Yoon CS, Than SS, Chua JM, Wong CY, Yong WS, Yap YS, Ho GH, Ang P, Lee AS. Evaluation of nanofluidics technology for high-throughput SNP genotyping in a clinical setting J MOL DIAGN 2011 13/305-312
Tan MH, Yang J, Tan HL, Wong CF, Tan PH, Sim HG, Ang P, Toh CK, Tay MH, Poon E, Ooi AS, Teh BT A unique pair of monozygotic twins with concordant clear cell renal cell carcinoma: a case report ANN ACAD MED SING 2010 39/61-63
Ang P ,Lim IHK, Yong RYY, Lee ASG A molecular approach for identifying individuals with Li–Fraumeni syndrome who have a limited family history CLIN GENET 2009 75/294-297
Lim WT, Tan EH, Toh CK, Hee SW, Leong SS, Ang P, Wong NS, Chowbay B. Phase I pharmacokinetic study of a weekly liposomal paclitaxel formulation (Genexol®-PM) in patients with solid tumors ANN ONCOL 2009 21/382-388
Lal S, Wong ZW, Sandanaraj E, Xiang X, Ang P, Lee EJ, Chowbay B Influence of ABCB1 and ABCG2 polymorphisms on doxorubicin disposition in Asian breast cancer patients CANCER SCI 2008 99/816-823
Wong ZW, Ang P, Chowbay B, Wong NS, See HT, Khoo KS Phase I/II study of gemcitabine with pegylated liposomal doxorubicin as first-line therapy in Asian women with metastatic breast cancer BREAST 2008 17/517-522
Gomez HL, Doval DC, Chavez MA, Ang PC, Aziz Z, Nag S, Ng C, Franco SX, Chow LW, Arbushites MC, Casey MA, Berger MS, Stein SH, Sledge GW Efficacy and Safety of Lapatinib As First-Line Therapy for ErbB2-Amplified Locally Advanced or Metastatic Breast Cancer J CLIN ONCOL 2008 26/2999-3005
Lal S, Sandanaraj E, Wong ZW, Ang P, Wong NS, Lee EJ, Chowbay B CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients CANCER SCI 2008 99/2045-2054
Sandanaraj E, Lal S, Selvarajan V, Ooi LL, Wong ZW, Wong NS, Ang P, Lee EJ, Chowbay B PXR pharmacogenetics: association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients CLIN CANCER RES 2008 14/7116-7126
Lee AS, Ang P CHEK2*1100delC screening of Asian women with a family history of breast cancer is unwarranted J CLIN ONCOL 2008 26/2419
Lal S, Wong ZW, Jada SR, Xiang X, Chen Shu X, Ang P, Figg WD, Lee EJ, Chowbay B Novel SLC22A16 polymorphisms and influence on doxorubicin pharmacokinetics in Asian breast cancer patients PHARMACOGENOMICS 2007 8/567-575
Ang P, Lim IH, Lee TC, Luo JT, Ong DC, Tan PH, Lee AS BRCA1 and BRCA2 Mutations in an Asian Clinic-based Population Detected Using a Comprehensive Strategy CANCER EPIDEM BIOMAR 2007 16/2276-2284
Chia, WK, Lim YL, Greaves MW, Ang P Toxic epidermal necrolysis in patient with breast cancer receiving letrozole LANCET ONCOL 2006 7/184-185
Fernandopulle SM, Ang P, Tan PH Breast carcinoma in women 35 years and younger: a pathological study PATHOLOGY 2006 38/219-222
Yap KL, Ang P, Lim IK, Ho G, Lee AG Detection of a novel Alu-mediated BRCA1 exon 13 duplication in Chinese breast cancer patients and implications for genetic testing CLIN GENET 2006 70/80-82
See HT, Cheung YB, Yong F, Khoo KS, Ang P Acceptance of prophylactic surgery and chemoprevention of cancer in Singapore - a survey. Ann Acad Med Singapore ANN ACAD MED SING 2005 34/238-242
Leong SS, Fong KW, Ong YK, Foo KF, Ang P, Wee J, Lee KM, Tan EH Chemo-radiotherapy for stage III unresectable non-small cell lung cancer long-term results of a prospective study RESPIR MED 2004 98/1080-1086
Leong SS, Tan EH, Fong KW, Wilder-Smith E, Ong YK, Tai BC, Chew L, Lim SH, Wee J, Lee KM, Foo KF, Ang P, Ang PT. Randomized Double-Blind Trial of Combined Modality Treatment With or Without Amifostine in Unresectable Stage III Non--Small-Cell Lung Cancer. J CLIN ONCOL 2003 1767-1774
See HT, Koo WH, Ang P, Au E, Ang PT Efficacy and tolerability of irinotecan in patients with advanced colorectal cancer in Singapore. ANN MED 2002 31/5/651-655
Ang P, Garber JE: Genetic susceptibility for breast cancer--risk assessment and counseling. SEMIN ONCOL 2001 28/419-433
Ang P, Tan EH, Leong SS, Koh L, Eng P, Agasthian T, Cheah FK: Primary intrathoracic malignant effusion: a descriptive study. CHEST 2001 120/50-54
Ang P, Cheong WK, Khoo KS: Pseudomembranous colitis in a patient treated with paclitaxel for carcinoma of the breast: a case report ANN MED 2000 29/132-134
Ang P, Chia KH, Teoh MK, Wong KK Use of a peripherally implanted subcutaneous permanent central venous access device for chemotherapy--the Singapore General Hospital experience AUST NZ J MED 2000 30/470-474
Low LL, Yip SK, Ang PC, Cheah FK: Testicular carcinoma with superior vena cava obstruction and atrial extension. UROLOGY 1999 54/363-364

Prizes/Awards

Description Year Organization/Country
Human Manpower Development Plan (HMDP) Fellowship in Clinical Genetics and Breast Cancer Medicine (USA) at Dana-Farber Cancer Institute, Boston, USA 2001   International
Exit certification and Singapore Specialist registration in Medical Oncology 2001 Specialist Accreditation Board/ International
Tan Siak Kew Scholarship for University Studies 1990   International
Ministry of Education scholarship for Junior College/Pre-University studies 1985   International
NCC Academic Awards – Best software development     International
Familial Cancer Risk Assessment and Management Exam certification by Institute of Clinical Evaluation     International
European Society of Medical Oncology (ESMO) certifying exam (2nd in score) for medical oncologists     International

Collaborations

Collapse Other
Project Institution/Organization Name Description From Year To Year
Singapore Cancer Network (SCAN) Breast Workgroup OncoCare Cancer Centre Singapore Cancer Network (SCAN) Guidelines for Adjuvant Trastuzumab Use in Early Stage HER2 Positive Breast Cancer 2014 Current
Singapore Cancer Network (SCAN) Breast Workgroup OncoCare Cancer Centre Singapore Cancer Network (SCAN) Guidelines for Bisphosphonate Use in the Adjuvant Breast Cancer Setting 2014 Current

Grant

Project Title
Beyond BRCA1 and BRCA2: Associations between new breast cancer susceptibility alleles and clinico-pathological characteristics in an Asian population, with implications for disease screening and breast cancer management
In vivo detection of multidrug resistant phenotype in breast cancer patients for neoadjuvant chemotherapy by scintimammography using 99m Tc-sestamibi scan and MDR1 genotyping
Singapore Breast Cancer Screening Project Part 2 - Validating absolute breast cancer risk prediction with the modified Gail model and health behaviour of subjects 8 years later.
Use of a risk assessment model for breast and ovarian cancer susceptibility in Asian women tested with BRCA1 and BRCA2 gene sequencing
Radiopharmaceutical Imaging to Predict and Evaluate the Response of Breast Cancer to Neoadjuvant Chemotherapy